Low-risk Drugs for G6PD Deficients

Low-risk drugs which can probably be given in NORMAL THERAPEUTIC DOSES to G-6-PD-deficient subjects without nonspherocytic hemolytic anemia
By Ernest Beutler, M.D. (see complete article here)


[Most important phrase to note here is "in normal therapeutic doses." Some of the listed drugs appear also in our To Avoid List under "low risk."]


  • Acetaminophen (paracetamol, Tylenol, Tralgon, hydroxyacetanilide)
  • Acetophenetidin (phenacetin)
  • Aminopyrine (Pyramidon, amidopyrine)
  • Antazoline (Antistine)
  • Antipyrine
  • Ascorbic acid (vitamin C)
  • Benzhexol (Artane)
  • Chloramphenicol [high risk for Mediterranean and Asian variants]
  • Chlorguanidine (Proguanil, Paludrine)
  • Chloroquine
  • Colchicine
  • Diphenhydramine (Benadryl)
  • Isoniazid
  • L-Dopa
  • Menadione sodium bisulfite (Hykinone)
  • Menapthone
  • p-Aminobenzoic acid
  • Phenylbutazone
  • Phenytoin
  • Probenecid (Benemid)
  • Procain amide hydrochlonde (Pronestyl)
  • Pyrimethamine (Daraprim)
  • Quinidine
  • Quinine
  • Streptomycin
  • Sulfacytine
  • Sulfadiazine
  • Sulfaguanidine
  • Sulfamerazine
  • Sulfamethoxypyridazine (Kynex)
  • Sulfisoxazole (Gantrisin)
  • Trimethoprim
  • Tripelennamine (pyribenzamine)
  • Vitamin K